TEACHING

CHEM 4670 - Drug Design and Drug Discovery

The course will give the student an understanding of the design, synthesis and interactions of drug molecules. Emphasis will be on the organic chemical principles and reactions vital to drug design and drug action. Upon completion of the course, the student should be able to demonstrate an understanding of the concepts involved in drug design and drug interactions, drug synthesis and biological evaluation.

Topics to be covered

1.
Drug Discovery, Design and Development
Drug Discovery, Lead Modification, Drug Design and Development Quantitative Structure-Activity Relationships

2.
Receptors
Introduction, Drug-Receptor Interactions, Interactions involved in the Drug Receptor Complex, Determination of Drug Receptor Interactions, Theories for Drug-Receptor Interactions, Topographical and Stereochemical Considerations

3.
Enzymes
Enzymes as catalysts, Mechanisms of Enzyme catalysis, Coenzyme Catalysis

4.
Enzyme Inhibition and Inactivation
Introduction, Drug Resistance, Drug Synergism, Reversible Enzyme Inhibition, Irreversible Enzyme Inhibition

5.
DNA-Interactive Agents
Introduction, DNA Structure and Properties, Classes of Drugs that interact with DNA

6. Drug Metabolism/Drug Delivery

LAST UPDATE: June 2016

Dr. Frank Schweizer
Full Professor
Departments of Chemistry
and Medical Microbiology
University of Manitoba
Winnipeg, MB
R3T 2N2

Office:460 Parker
Labs: 448, 446 & 382 Parker

Tel: (204) 474-7012
Fax: (204) 474-7608
email:
schweize@cc.umanitoba.ca

CHEM 7450 - Recent Developments in Organic and Carbohydrate Chemistry

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