Refereed Articles

  1. Lopes, L.C.; Jiang, A.; Zarychta, M.; Wiebe, K.; Ramirez, D.; Schweizer, F.; and Kuss, S. Electrochemical Detection of Tobramycin Resistance in Escherichia coli. J. Electrochem. Soc. 171, 095502 (2024).
  2. Zhanel, G.G.; Mansour, C.; Mikolayanko, S.; Lawrence, C.K.; Zelenitsky, S.; Ramirez, D.; Schweizer, F.; Bay, D.; Adam, H.; Lagacé-Wiens, P.; Walkty, A.; Irfan, N.; Clark, N.; Nicolau, D.; Tascini, C.; and Karlowsky, J.A. Cefepime-Taniborbactam: A Novel Cephalosporin/β-Lactamase Inhibitor Combination. Drugs (2024).
  3. Dhiman, S.; Ramirez, D.; Arora, R.; Arthur, G.; and Schweizer, F. Enhancing Outer Membrane Permeability of Tetracycline Antibiotics in P. aeruginosa using TOB-CIP Conjugates. RSC Med. Chem. 15, 3133-3146 (2024).
  4. Berry, L.; Ramirez, D.; Domalaon, R.; and Schweizer, F. Sulfonamide Bioisosteres of Niclosamide Enhance Antibacterial Activity of Colistin and Bacitracin. ChemMedChem 19, e202400175 (2024).
  5. Ramirez, D.M.; Dhiman, S.; Mukherjee, A.; Wimalasekara, R.; and Schweizer, F. Application of Tobramycin Benzyl Ether as an Antibiotic Adjuvant Capable of Sensitizing Multidrug-Resistant Gram-Negative Bacteria to Rifampicin. RSC Med. Chem. 15, 1055-1065 (2024).
  6. Berry, L.; Neale, Q.; Arora, R.; Ramirez, D.; Brizuela, M; Domalaon, R.; Arthur, G.; and Schweizer F. Exploring Structure-Activity Relationships of Niclosamide-Based Colistin Potentiators in Colistin-Resistant Gram-Negative Bacteria. Antibiotics 13, 43 (2024).
  7. Gandhi, K.; Dhiman, S.; Arora, R.; Ramirez, D.M.; Ramirez, D.; Arthur, G.; and Schweizer, F. Exploring Antibiotic-Potentiating Effects of Tobramycin-Deferiprone Conjugates in Pseudomonas aeruginosa. Antibiotics 12, 1261 (2023).
  8. Ramirez, D.M.; Ramirez, D.; Dhiman, S.; Arora, R.; Lozeau, C.; Arthur, G.; Zhanel, G.; and Schweizer, F. Guanidinylated Amphiphilic Tobramycin Derivatives Synergize with β-Lactam/β-Lactamase Inhibitor Combinations against Pseudomonas aeruginosa. ACS Infect. Dis. 9, 1754-1768 (2023).
  9. Dhiman, S.; Ramirez, D.; Arora, R.; Gandhi, K.; Wimalesekara, R.; Arthur, G.; Kumar, A.; and Schweizer, F. Trimeric Tobramycin/Nebramine Synergizes Antibiotics against Pseudomonas aeruginosa. ACS Omega 8, 29359-29373 (2023).
  10. Mukherjee, A.; Ramirez, D.; Arora, R.; Arthur, G.; and Schweizer, F. Amphiphilic Tribasic Galactosamines Potentiate Rifampicin in Gram-Negative Bacteria in Low Mg++/Ca++ Concentrations. Bioorg. Med. Chem. Lett. 97, 129371 (2024).
  11. Dhiman, S.; Ramirez, D.; Li, Y.; Kumar, A.; Arthur, G.; and Schweizer, F. Chimeric Tobramycin-Based Adjuvant TOB-TOB-CIP Potentiates Fluoroquinolone and β-Lactam Antibiotics against Multidrug-Resistant Pseudomonas aeruginosa. ACS Infect. Dis. 9, 864-885 (2023).
  12. Ramirez, D.M.; Ramirez, D.; Arthur, G.; Zhanel, G.G.; Schweizer, F. Guanidinylated Polymyxins as Outer Membrane Permeabilizers Capable of Potentiating Rifampicin, Erythromycin, Ceftazidime and Aztreonam against Gram-Negative Bacteria. Antibiotics 11, 1277 (2022).
  13. Nachtigal, M.W.; Altman, A.D.; Arora, R.; Schweizer, F.; Arthur, G. The Potential of Novel Lipid Agents for the Treatment of Chemotherapy-Resistant Human Epithelial Ovarian Cancer. Cancers 14, 3318 (2022).
  14. Karlowsky, J.A.; Walkty, A.J.; Baxter, M.R.; Adam, H.J.; Lagacé-Wiens, P.R.S.; Schweizer, F.; Bay, D.; Lynch, J.P.; Mulvery, M.R.; Zhanel, G.G. In Vitro Activity of Cefiderocol against Extensively Drug-Resistant Pseudomonas aeruginosa: CANWARD, 2007 to 2019. Microbiol. Spectr. 10 (2022).
  15. Zhanel, G.G.; Pozdirca, M.; Golden, A.R.; Lawrence, C.K.; Zelenitsky, S.; Berry, L.; Schweizer, F.; Bay, D.; Adam, H.; Zhanel, M.A.; Lagacé-Wiens, P.R.S.; Walkty, A.; Irfan, N.; Naber, K.; Lynch, J.P.; Karlowsky, J.A. Sulopenem: An Intravenous and Oral Penem for the Treatment of Urinary Tract Infections Due to Multidrug-Resistant Bacteria. Drugs 82, 533-557 (2022).
  16. Schweizer, L.; Ramirez, D.; Schweizer, F. Effects of Lysine N-ζ-Methylation in Ultrashort Tetrabasic Lipopeptides (UTBLPs) on the Potentiation of Rifampicin, Novobiocin, and Niclosamide in Gram-Negative Bacteria. Antibiotics 11, 335 (2022).
  17. Ramirez, D.; Berry, L.; Domalaon, R.; Li, Y.; Arthur, G.; Kumar, A.; Schweizer, F. Dioctanoyl Ultrashort Tetrabasic β-peptides Sensitize Multidrug-Resistant Gram-Negative Bacteria to Novobiocin and Rifampicin. Front. Microbiol. 12, 803309 (2021).
  18. Golden, A.R.; Baxter, M.R.; Karlowsky, J.A.; Mataseje, L.; Mulvey, M.R.; Walkty, A.; Bay, D.; Schweizer, F.; Lagacé-Wiens, P.R.S.; Adam, H.J.; Zhanel, G.G. Activity of cefepime/taniborbactam and comparators against whole genome sequenced ertapenem-non-susceptible Enterobacterales clinical isolates: CANWARD 2007-19. JAC Antimicrob Resist 4, dlab197 (2021).
  19. Nachtigal, M.W.; Musaphir, P.; Dhiman, S.; Altman, A.D.; Schweizer, F.; Arthur, G. Cytotoxic capacity of a novel glycosylated antitumor ether lipid in chemotherapy-resistant high grade serous ovarian cancer in vitro and in vivo. Transl. Oncol. 40, 101203 (2021).
  20. Hada, N.; Morita, T.; Ueda, T.; Masuda, K.; Nakane, H.; Ogane, M.; Yamano, K.; Schweizer, F.; Kiuchi, F. Synthesis of the Carbohydrate Moiety of Glycoproteins from the Parasite Echinococcus granulosus and Their Antigenicity against Human Sera. Molecules 26, 5652 (2021).
  21. Berry, L.; Brizuela, M; Jackson, G.; Schweizer, F. A niclosamide-tobramycin hybrid adjuvant potentiates cefiderocol against P. aeruginosa. RSC Med. Chem. 12, 1565-1573 (2021).
  22. Zhanel, G.G.; Deng, C.; Zelenitsky, S.; Lawrence, C.K.; Adam, H.J.; Golden, A.; Berry, L.; Schweizer, F.; Zhanel, M.A.; Irfan, N.; Bay, D.; Lagacé-Wiens, P.R.S.; Walkty, A.; Mandell, L.; Lynch, J.P.; Karlowsky, J.A. Lefamulin: A Novel Oral and Intravenous Pleuromutilin for the Treatment of Community-Acquired Bacterial Pneumonia. Drugs 81, 233-356 (2021).
  23. Idowu, T.; Ammeter, D.; Brizuela, M.; Jackson, G.; Alam, S.; Schweizer, F. Overcoming β-Lactam resistance in Pseudomonas aeruginosa using non-canonical tobramycin-based antibiotic adjuvants. Bioorg. Med. Chem. Lett. 30, 127575 (2020).
  24. Islam, R.; Singh, V.; Ammeter, D.; Schweizer, F.; Kuss, S. Electrochemical characterization of the antibiotic hybrid ciprofloxacin-tobramycin. Electrochem. Commun. 119, 106825 (2020).
  25. Ramirez, D.; Berry, L.; Domalaon, R.; Brizuela, M.; Schweizer, F. Dilipid Ultrashort Tetrabasic Peptidomimetics (dUSTBPs) Potentiate Novobiocin and Rifampicin against Multidrug-resistant Gram-negative Bacteria. ACS Infect. Dis. 6, 1413-1426 (2020).
  26. Zhanel, G.G.; Esquivel, J.; Zelenitsky, S.; Lawrence, C.K.; Adam, H.J.; Golden, A.; Hink, R.; Berry, L.; Schweizer, F.; Zhanel, M.A.; Bay, D.; Lagacé-Wiens, P.R.S.; Lynch, J.P.; Karlowsky, J.A. Omadacycline: A Novel Oral and Intravenous Aminomethylcycline Antibiotic Agent. Drugs 80, 285-313 (2020).
  27. Ogunsina, M.; Samadder, P.; Idowu, T.; Nachtigal, M.; Schweizer, F.; Arthur, G. Syntheses of L-Rhamnose-linked amino glycerolipids and their cytotoxic activities against human cancer cells. Molecules 25, 566 (2020).
  28. Idowu, T.; Zhanel, G.G.; Schweizer, F. A dimer, but not monomer, of tobramycin potentiates Ceftolozane against multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa and delays resistance development. Antimicrob. Agents Chemother. 64, e02055-19 (2020).
  29. Ammeter, D.; Idowu, T.; Zhanel, G.G.; Schweizer, F. Development of a nebramine-cyclam conjugate as an antibacterial adjuvant to potentiate ß-lactam antibiotics against multidrug-resistant P. aeruginosa. J. Antibiot. 72, 816-826 (2019).
  30. Idowu, T.; Ammeter, D.; Rossong, H.; Zhanel, G.G.; Schweizer, F. Homodimeric Tobramycin Adjuvant Repurposes Novobiocin as an Effective Antibacterial Agent against Gram-Negative Bacteria. J. Med. Chem. 62, 9103-9115 (2019).
  31. Idowu, T.; Ammeter, D.; Arthur, G.; Zhanel, G.G.; Schweizer, F. Potentiation of ß-lactam antibiotics and ß-lactam/ß-lactamase inhibitor combinations against MDR and XDR Pseudomonas aeruginosa using non-ribosomal tobramycin-cyclam conjugates. J. Antimicrob. Chemother. 74, 2640-2648 (2019).
  32. Domalaon, R.; Okunnu, O.; Zhanel, G.G.; Schweizer, F. Synergistic combinations of anthelmintic salicylanilides oxyclozanide, rafoxanide, and closantel with colistin eradicates multidrug-resistant colistin-resistant Gram-negative bacilli. J. Antibiot. 72, 605-616 (2019).
  33. Yang, X.; Ammeter, D.; Idowu, T.; Domalaon, R.; Brizuela, M.; Okunnu, O.; Bi, L.; Guerrero, Y.A.; Zhanel, G.G.; Kumar, A.; Schweizer, F. Amphiphilic nebramine-based hybrids Rescue legacy antibiotics from intrinsic resistance in multidrug-resistant Gram-negative bacilli. Eur. J. Med. Chem. 175, 187-200 (2019).
  34. Zhanel, G.G.; Adam, H.J.; Baxter, M.R.; Fuller, J.; Nichol, K.A.; Denisuik, A.J.; Golden, A.R.; Hink, R.; Lagacé-Wiens, P.R.S.; Walkty, A.; Mulvey, M.R.; Schweizer, F.; Bay, D.; Hoban, D.J.; Karlowsky, J.A.; Canadian Antimicrobial Resistance Alliance (CARA), CANWARD. 42936 pathogens from Canadian hospitals: 10 years of results (2007-16) from the CANWARD surveillance study. J. Antimicrob. Chemother. 74 (Supplement_4), iv5-iv21 (2019).
  35. Idowu, T.; Arthur, G.; Zhanel, G.G.; Schweizer, F. Heterodimeric Rifampicin-Tobramycin conjugates break intrinsic resistance of Pseudomonas aeruginosa to doxycycline and chloramphenicol in vitro and in a Galleria mellonella in vivo model. Eur. J. Med. Chem. 174, 16-32 (2019).
  36. Domalaon, R.; Malaka De Silva, P.; Kumar, A.; Zhanel, G.G.; Schweizer, F. The anthelmintic drug niclosamide synergizes with colistin and reverses colistin resistance in Gram-negative bacilli. Antimicrob. Agents Chemother. 63, e02574-18 (2019).
  37. Domalaon, R.; Brizuela, M.; Eisner, B.; Findlay, B.; Zhanel, G.G.; Schweizer, F. Dilipid ultrashort cationic lipopeptides as adjuvants for chloramphenicol and other conventional antibiotics against Gram-negative bacteria. Amino Acids 51, 383-393 (2019).
  38. Zhanel, G.G.; Golden, A.R.; Zelenitsky, S.; Wiebe, K.; Lawrence, C.K.; Adam, H.J.; Idowu, T.; Domalaon, R.; Schweizer, F.; Zhanel, M.A.; Lagacé-Wiens, P.R.S.; Walkty, A.J.; Noreddin, A.; Lynch, J.P.; Karlowsky, J.A. Cefiderocol: A Siderophore Cephalosporin with Activity Against Carbapenem-Resistant and Multidrug-Resistant Gram-Negative Bacilli. Drugs 79, 271-289 (2019).
  39. Schweizer, F. Enhancing uptake of antibiotics into Gram-negative bacteria using nonribosome-targeting aminoglycoside-based adjuvants. Future Med. Chem. 11, 1519-1522 (2019).
  40. Lyu, Y.; Domalaon, R.; Yang, X.; Schweizer, F. Amphiphilic lysine conjugated to tobramycin synergizes legacy antibiotics against wild-type and multidrug-resistant Pseudomonas aeruginosa. Peptide Science 111, e23091 (2019).
  41. Berry, L.; Domalaon, R.; Brizuela, M.; Zhanel, G.G.; Schweizer, F. Polybasic peptide-levofloxacin conjugates potentiate fluoroquinolones and other classes of antibiotics against multidrug-resistant Gram-negative bacteria. Medchemcomm 10, 517-527 (2019).
  42. Domalaon, R.; Ammeter, D.; Brizuela, M.; Gorityala, B.K.; Zhanel, G.G.; Schweizer, F. Repurposed antimicrobial combination therapy: Tobramycin-ciprofloxacin hybrid augments activity of the anticancer drug mitomycin C against multidrug-resistant Gram-negative bacteria. Front. Microbiol. 10, 1556 (2019).
  43. Hada, N.; Umeda, Y.; Kumada, H.; Shimazaki, Y.; Yamano, K.; Schweizer, F.; Oshima, N.; Takeda, T.; Kiuchi, F. Synthesis of the Non Reducing End Oligosaccharides of Glycosphingolipids from Ascaris suum. Chem. Pharm. Bull. 67, 143-154 (2019).
  44. Domalaon, R.; Berry, L.; Tays, Q.; Zhanel, G.G.; Schweizer, F. Development of dilipid polymyxins: Investigation on the effect of hydrophobicity through its fatty acyl component. Bioorg. Chem. 80, 639-648 (2018).
  45. Yang, X.; Domalaon, R.; Lyu, Y.; Zhanel, G.G.; Schweizer, F. Tobramycin-Linked Efflux Pump Inhibitor Conjugates Synergize Fluoroquinolones, Rifampicin and Fosfomycin against Multidrug-Resistant Pseudomonas aeruginosa. J. Clin. Med. 7, 158 (2018).
  46. Roy, R.; Ang, E.; Komatsu, E.; Domalaon, R.; Bosseboeuf, A.; Harb, J.; Hermouet, S.; Krokhin, O.; Schweizer, F.; Perreault, H. Absolute Quantitation of Glycoforms of Two Human IgG Subclasses Using Synthetic Fc Peptides and Glycopeptides. J. Am. Soc. Mass Spectrom. 29, 1086-1098 (2018).
  47. Zhanel, G.G.; Lawrence, C.K.; Adam, H.; Schweizer, F.; Zelenitsky, S.; Zhanel, M.; Lagacé-Wiens, P.R.S.; Walkty, A.; Denisuik, A.; Golden, A.; Gin, A.S.; Hoban, D.J.; Lynch, J.P., Karlowsky, J.A. Correction to: Imipenem-Relebactam and Meropenem-Vaborbactam: Two Novel Carbapenem-ß-Lactamase Inhibitor Combinations (Drugs (2018), 78, 1, (65-98)). Drugs 78, 787 (2018).
  48. Domalaon, R.; Idowu, T.; Zhanel, G.G.; Schweizer, F. Antibiotic Hybrids: the next generation of agents and adjuvants against gram-negative pathogens?. Clin. Microbiol. Rev. 31, e00077-17 (2018).
  49. Domalaon, R.; Sanchak, Y.; Cherono Koskei, L.; Lyu, Y.; Zhanel, G.G.; Arthur, G.; Schweizer, F. Short proline-rich lipopeptide potentiates minocycline and rifampin against multidrug- and extensively drug-resistant Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 62, e02374-17 (2018).
  50. Idowu, T.; Samadder, P.; Arthur, G.; Schweizer, F. Amphiphilic Modulation of Glycosylated Antitumor Ether Lipids Results in a Potent Triamino Scaffold against Epithelial Cancer Cell Lines and BT474 Cancer Stem Cells. J. Med. Chem. 60, 9724-9738 (2017).
  51. Domalaon, R.; Yang, X.; Lyu, Y.; Zhanel, G.G.; Schweizer, F. Polymyxin B3-Tobramycin Hybrids with Pseudomonas aeruginosa-Selective Antibacterial Activity and Strong Potentiation of Rifampicin, Minocycline, and Vancomycin. ACS. Infect. Dis. 3, 941-954 (2017).
  52. Kanaya, T.; Mashio, R.; Watanabe, T.; Schweizer, F.; Hada, N. Synthesis of glycosphingolipids from the fungus Hirsutella rhossiliensis. Tetrahedron 73, 6847-6855 (2017).
  53. Idowu, T.; Schweizer, F. Ubiquitous nature of fluoroquinolones: The oscillation between antibacterial and anticancer activities. Antibiotics 6, 26 (2017).
  54. Moraya, A.I.; Ali, J.L.; Samadder, P.; Liang, L.; Morrison, L.C.; Werbowetski-Ogilvie, T.E.; Ogunsina, M.; Schweizer, F.; Arthur, G.; Nachtigal, M.W. Novel glycolipid agents for killing cisplatin-resistant human epithelial ovarian cancer cells. J. Exp. Clin. Cancer. Res. 36, 67 (2017).
  55. Yang, X.; Goswami, S.; Gorityala, B.K.; Domalaon, R.; Lyu, Y.; Kumar, A.; Zhanel, G.G.; Schweizer, F. A Tobramycin Vector Enhances Synergy and Efficacy of Efflux Pump Inhibitors against Multidrug-Resistant Gram-Negative Bacteria. J. Med Chem. 60, 3913-3932 (2017).
  56. Lyu, Y.; Yang, X.; Goswami, S.; Gorityala, B.K.; Idowu, T.; Domalaon, R.; Zhanel, G.G.; Shan, A.; Schweizer, F. Amphiphilic Tobramycin-Lysine Conjugates Sensitize Multidrug Resistant Gram-Negative Bacteria to Rifampicin and Minocycline. J. Med. Chem. 60, 3684-3702 (2017).
  57. Ogunsina, M.; Samadder, P.; Idowu, T.; Arthur G.; Schweizer, F. Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells. J. Med. Chem. 60, 2142-2147 (2017).
  58. McLellan, M.; Doyle, M.G.J.; Bodnar, E.D.; Lopez, P.G.; Domalaon, R.; Roy, R.; Cordova, K.; Schweizer, F.; Perreault, H. Multiplexed azido-group isotopic capture (MAGIC) beads: Selective analysis of azido compounds using a propargyl-based cleavable linker, a proof of concept. Rapid Commun. Mass Spectrom. 30, 2487-2507 (2016).
  59. Zhanel, G.G.; Hartel, E.; Adam, H.; Zelenitsky, S.; Zhanel, M.A.; Golden, A.; Schweizer, F.; Gorityala, B.; Lagacé-Wiens, P.R.S.; Walkty, A.J.; Gin, A.S.; Hoban D.J.; Lynch, J.P., Karlowsky, J.A. Solithromycin: A Novel Fluoroketolide for the Treatment of Community-Acquired Bacterial Pneumonia. Drugs 76, 1737-1757 (2016).
  60. Domalaon, R.; Findlay, B.; Ogunsina, M.; Arthur, G.; Schweizer, F. Ultrashort cationic lipopeptides and lipopeptoids: Evaluation and mechanistic insights against epithelial cancer cells. Peptides 84, 58-67 (2016).
  61. Gorityala, B.K.; Guchhait, G.; Goswami, S.; Fernando, D.M.; Kumar, A.; Zhanel, G.G.; Schweizer, F. Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux. J. Med. Chem. 59, 8441-8455 (2016).
  62. Domalaon, R.; Zhanel. G.G.; Schweizer, F. Short antimicrobial peptides and peptide scaffolds as promising antibacterial agents. Curr. Top. Med. Chem. 16, 1217-1230 (2016).
  63. Akbari-Birgani, S.; Paranjothy, T.; Zuse, A.; Janikowski, T.; Cieślar-Pobuda, A.; Likus, W.; Urasińska, E.; Schweizer, F.; Ghavami, S.; Klonisch, T.; Łos, M.J. Cancer stem cells, cancer initiating cells and methods for their detection. Drug Discov. Today 21, 836-842 (2016).
  64. Zhanel G.G.; Cheung, D.; Adam H.; Zelenitsky, S.; Golden, A.; Schweizer, F.; Gorityala, B.; Lagacé-Wiens, P.R.S.; Walkty, A.; Gins, A.S.; Hoban, D.J.; Karlowsky, J.A. Review of Eravacycline, a Novel Fluorocycline Antibacterial Agent. Drugs 76, 567-588 (2016).
  65. Gorityala, B.K.; Guchhait, G.; Fernando, D.M.; Deo, S.; McKenna, S.A.; Zhanel, G.G.; Kumar, A.; Schweizer, F. Adjuvants based on hybrid antibiotics overcome resistance in Pseudomonas aeruginosa and enhance fluoroquinolone efficacy. Angew. Chem. Intl. Ed. Engl. 55, 555-559 (2016).
  66. Bera, S.; Mondal, D.; Palit, S.; Schweizer, F. Structural modifications of the neomycin class of aminoglycosides. Medchemcomm 7, 1499-1534 (2016).
  67. Idowu, T.; Samadder, P.; Arthur, G.; Schweizer, F. Design, synthesis and antitumor properties of glycosylated antitumor ether lipid (GAEL)-chlorambucil-hybrids. Chem. Phys. Lipids 194, 139-148 (2016).
  68. Ogunsina, M.; Samadder, P.; Idowu, T.; Arthur, G.; Schweizer, F. Design, synthesis and evaluation of cytotoxic properties of bisamino glucosylated antitumor ether lipids against cancer cells and cancer stem cells. Medchemcomm 7, 2100-2110 (2016).
  69. Hada, N.; Kitamura, A.; Yamano, K.; Schweizer, F.; Kiuchi, F. Synthesis and antigenicity against human sera of biotin-labeled oligosaccharide portion of a glycosphingolipid from the parasite Echinococcus multilocularis. Chem. Pharm. Bull. 64, 865-873 (2016).
  70. Guchhait, G.; Altieri, A.; Gorityala, B.; Yang, X.; Findlay, B.; Zhanel. G.G.; Mookherjee, N.; Schweizer, F. Amphiphilic tobramycins with immunomodulatory properties. Angew. Chem. Intl. Ed. 54, 6278-6282 (2015).
  71. Jain, M.V.; Jangamreddy, J.R.; Grabarek, J; Schweizer, F.; Klonisch, T.; Cieślar-Pobuda, A.; Łos, M.J. Nuclear localized Akt enhances breast cancer stem-like cells through counter-regulation of p21(Waf1/Cip1) and p27(kip1). Cell Cycle 14, 2109-2120 (2015).
  72. Zhanel, G.G.; Love, R.; Adam, H.; Golden, A.; Zelenitsky, S.; Schweizer, F.; Gorityala, B.; Lagacé-Wiens, P.R.S.; Rubinstein, E.; Walkty, A.; Gin, A.S.; Gilmour, M.; Hoban, D.J.; Lynch, J.P.; Karlowsky, J.A. Tedizolid: A novel oxazolidinone with potent activity against multidrug-resistant Gram-positive pathogens. Drugs 75, 253-270 (2015)
  73. Samadder, P.; Xu, Y.; Schweizer, F.; Arthur, G. Cytotoxic properties of d-gluco, d-galacto and d-manno-configured 2-amino-2-deoxy-glycerolipids against epithelial cancer cell lines and BT-474 breast cancer stem cells. Eur. J. Med. Chem. 78, 225-235 (2014).
  74. Domalaon, R.; Yang, X.; O'Neil, J.; Zhanel, G.G.; Mookherjee, N.; Schweizer, F. Structure activity relationships in ultrashort cationic lipopeptides: The effects of amino acid ring constraint on antibacterial activity. Amino Acids 46, 2517-2530 (2014).
  75. Zhanel G.G.; Chung, P.; Adam, H.; Zelenitsky, S.; Denisuik, A.; Schweizer, F.; Lagacé-Wiens, P.R.S.; Rubinstein, E.; Gin, A.S.; Walkty, A.; Hoban, D.J.; Lynch, J.P.; Karlowsky, J.A. Ceftolozane/tazobactam: A novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant Gram-negative bacilli. Drugs 74, 31-51 (2014).
  76. Ogunsina, M.; Pan, H.; Samadder, P.; Arthur, G.; Schweizer, F. Structure activity relationships of N-linked and diglycosylated glucosamine-based antitumor glycerolipids. Molecules 18, 15288-15304 (2013).
  77. Naziga, E.B.; Schweizer, F.; Wetmore, S.D. Solvent interactions stabilize the polyproline II conformation of glycosylated oligoprolines. J. Phys. Chem. B 117, 2671-2681 (2013).
  78. Xu, Y.; Ogunsina, M.; Samadder, P.; Arthur, G.; Schweizer, F. Structure-Activity Relationships of Glucosamine-Derived Glycerolipids: The Role of the Anomeric Linkage, the Cationic Charge and the Glycero Moiety on Antitumor Activity. ChemMedChem 8, 511-520 (2013).
  79. Findlay, B.; Mookherjee, N.; Schweizer, F. Ultrashort Cationic Lipopeptides and Lipopeptoids Selectively Induce Cytokine Production in Macrophages. PLoS ONE 8, e54280 (2013).
  80. Zhanel, G.G.; Lawson, C.D.; Adam, H.; Schweizer, F.; Zelenitsky, S.; Lagacé-Wiens, P.R.S.; Denisuik, A.; Rubinstein, E.; Gin, A.S.; Hoban, D.J.; Lynch, J.P.; Karlowsky, J.A. Ceftazidime-avibactam: A novel cephalosporin/β-lactamase inhibitor combination. Drugs 73, 159-177 (2013).
  81. Teklebrhan, R.B.; Owens, N.W.; Xidos, J.D.; Schreckenbach, G.; Wetmore, S.D.; Schweizer, F. Conformational preference of fused carbohydrate-templated proline analouges - A computational study. J. Phys. Chem. B 117, 199-205 (2013).
  82. Zhanel, G.G.; Adam, H.J.; Baxter, M.R.; Fuller, J.; Nichol, K.A.; Denisuik, A.J.; Lagacé-Wiens, P.R.S.; Walkty, A.; Karlowsky, J.A.; Schweizer, F.; Hoban, D.J.; Canadian Antimicrobial Resistance Alliance (CARA). Antimicrobial susceptibility of 22746 pathogens from Canadian hospitals; results of the CANWARD 2007-11 study. J. Antimicrob. Chemother. 68 (Suppl 1), i7-i22 (2013).
  83. Jain, M.V.; Paczulla, A.M.; Klonisch, T.; Dimgba, F.N.; Rao, S.B.; Roberg, K.; Schweizer, F.; Lengerke, C.; Davoodpour, P.; Palicharla, V.R.; Maddika, S.; Los, M. Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development. J. Cell. Mol. Med. 17, 12-29 (2013).
  84. Kanaya, T.; Schweizer, F.; Takeda, T.; Kiuchi, F.; Hada, N. Synthetic studies on glycosphingolipids from protostomia phyla: Synthesis of glycosphingolipids and related carbohydrate moieties from the parasite Schistosoma mansoni. Carbohydr. Res. 361, 55-72 (2012).
  85. Dhondikubeer, R.; Bera, S.; Zhanel, G.G.; Schweizer, F. Antibacterial activity of amphiphilic tobramycin. J. Antibiot. 65, 495-498 (2012).
  86. Bera, S.; Dhondikubeer, R.; Findlay, B.; Zhanel, G.G.; Schweizer, F. Synthesis and antibacterial activities of amphiphilic neomycin B-based bilipid conjugates and fluorinated neomycin B-based lipids. Molecules 17, 9129-9141 (2012).
  87. Koizumi, A.; Yamano, K.; Tsuchiya, T.; Schweizer, F.; Kiuchi, F.; Hada, N. Synthesis, antigenicity against human sera and structure activity relationships of carbohydrate moiety from toxocara larvae and their analogues. Molecules 17, 9023-9042 (2012).
  88. Findlay, B.; Szelemej, P.; Zhanel, G.G. Schweizer, F. Guanidylation and tail effects in cationic antimicrobial lipopeptoids. PLoS ONE 7, e41141 (2012).
  89. Findlay, B.; Zhanel, G.G.; Schweizer, F. Investigating the antimicrobial peptide ‘window of activity’ using cationic lipopeptides with hydrocarbon and fluorinated tails. Int. J. Antimicrob. Agents 40, 36-42 (2012).
  90. Zhanel, G.G.; Schweizer, F.; Karlowsky, J.A. Oritavancin: Mechanism of action. Clin. Infect. Dis. 54 (Suppl 3), S214-S219 (2012).
  91. Zhanel, G.G.; Lawson, C.D.; Zelenitsky, S.; Findlay, B.; Schweizer, F.; Adam, H.; Walkty, A.; Rubinstein, E.; Gin, A.S.; Hoban, D.J.; Lynch J,P.; Karlowsky, J.A. Comparison of the next-generation aminoglycoside plazomicin to gentamicin, tobramycin and amikacin. Expert Rev. Anti Infect. Ther. 10, 459-473 (2012).
  92. Findlay, B.; Zhanel, G.G.; Schweizer, F. Neomycin-phenolic conjugates: Polycationic amphiphiles with broad-spectrum antibacterial activity, low hemolytic activity and weak serum protein binding. Bioorg. Med. Chem. Lett. 22, 1499-1503 (2012).
  93. Naziga, E.B.; Schweizer, F.; Wetmore, S.D. Conformational study of the hydroxyproline-O-glycosidic linkage: Sugar-peptide orientation and prolyl amide isomerization in (α/β)-galactosylated 4(R/S)-hydroxyproline. J. Phys. Chem. B 116, 860-871 (2012).
  94. Koizumi, A.; Yamano, K.; Schweizer, F.; Takeda, T.; Kiuchi, F.; Hada, N. Synthesis of the carbohydrate moiety of the parasite Echinococcus multilocularis and their antigenicity against human sera. Eur. J. Med. Chem. 46, 1768-1778 (2011).
  95. Zhanel, G.G.; Calic, D.; Schweizer, F. Erratum: New lipoglycopeptides: A comparative review of dalbavancin, oritavancin and telavancin (Drugs (2010), 70, 7, (859-886)). Drugs 71, 526 (2011).
  96. Mondal, D.; Zhanel, G.G.; Schweizer, F. Synthesis and antibacterial properties of carbohydrate-templated lysine surfactants. Carbohydr. Res. 346, 588-594 (2011).
  97. Bera, S.; Zhanel, G.G.; Schweizer, F. Synthesis and antibacterial activity of amphiphilic lysine-ligated neomycin B conjugates. Carbohydr. Res. 346, 560-568 (2011).
  98. Fujita, Y.; Ohshima, N.; Hasegawa, A.; Schweizer, F.; Takeda, T.; Kiuchi, F.; Hada, N.; Synthesis, inhibitory effects on nitric oxide and structure-activity relationships of a glycosphingolipid from the marine sponge Aplysinella rhax and its analogues. Molecules 16, 637-651 (2011).
  99. Zhanel, G.G.; Decorby, M.; Adam, H.; Mulvey, M.R.; McCracken, M.; Lagacé-Wiens, P.R.S.; Nichol, K.A.; Wierzbowski, A.; Baudry P.J.; Tailor, F.; Karlowsky, J.A.; Walkty, A.; Schweizer, F.; Johnson, J.; Hoban D.J. Prevalence of antimicrobial-resistant pathogens in Canadian hospitals: results of the Canadian ward surveillance study (CANWARD 2008). Antimicrob. Agents Chemother. 54, 4684-4693 (2010).
  100. Findlay, B.; Zhanel, G.G.; Schweizer, F. Cationic amphiphiles, a new generation of antimicrobials inspired by the natural antimicrobial scaffold. Antimicrob. Agents Chemother. 54, 4049-4058 (2010).
  101. Teklebrhan R.B.; Zhang, K.; Schreckenbach, G.; Schweizer, F.; Wetmore, S.D. Intramolecular hydrogen-bond controlled prolyl amide isomerization in glucosyl 3(S)-hydroxy-5-hydroxymethylproline hybrids: a computational study. J. Phys. Chem. B 114, 11594-11602 (2010).
  102. Mondal, D.; Schweizer, F. Synthesis of allose-templated hydroxyornithine and hydroxyarginine analogues. Carb. Res. 345, 1533-1540, (2010).
  103. Zhang, K.; Schweizer, F. Influence of glucose-templated proline mimetics on the turn conformation of the peptide fragment Ac-Leu-D-Phe-Pro-Val-NMe2 found in Gramicidin S. Carb. Res. 345, 1114-1122 (2010).
  104. Bera, S.; Zhanel, G.G.; Schweizer, F. Evaluation of amphiphilic aminoglycoside-peptide triazole conjugates as antibacterial agents. Bioorg. Med. Chem. Lett. 20, 3031-3035 (2010).
  105. Bera, S.; Zhanel, G.G.; Schweizer, F. Antibacterial activities of aminoglycoside antibiotics-derived cationic amphiphiles. Polyol-modified neomycin B-, kanamycin A-, amikacin- and neamine-based amphiphiles with potent broad-spectrum antibacterial activity. J. Med. Chem. 53, 3626-3631 (2010).
  106. Owens, N.W.; Stetefeld, J.; LattovaÌ, E.; Schweizer, F. Contiguous O-galactosylation of 4R-hydroxy-L-proline residues forms very stable polyproline II helices. J. Am. Chem. Soc. 132, 5036-5042 (2010).
  107. Bera, S.; Zhanel, G.G.; Schweizer, F. Antibacterial activity of guanidinylated neomycin B- and kanamycin A-derived amphiphilic lipid conjugates. J. Antimicrob. Chemother. 65, 1224-1227 (2010).
  108. Kanaya, T.; Yagi, S.; Schweizer, F.; Takeda, T.; Kiuchi, F.; Hada, N. Synthetic studies on glycosphingolipids from protostomia phyla: synthesis of glycosphingolipids from the parasite Schistosoma mansoni. Chem. Pharm. Bull. (Tokyo) 58, 811-817 (2010).
  109. Schweizer, F. Cationic amphiphilic peptides with cancer-selective toxicity. Eur. J. Pharmcol. 625, 190-194 (2009).
  110. Owens, N. W.; Lee, A.; Marat, K.; Schweizer, F. The implications of (2S,4S)-hydroxyproline 4-O-glycosylation for prolyl amide isomerization. Chem. Eur. J. 15, 10649-10657 (2009).
  111. Hada, N.; Shida, Y.; Negishi, N.; Schweizer, F.; Takeda, T. Syntheses of glycoclusters containing a phosphocholine residue related to a glycosphingolipid from the earthworm Pheretima hilgendorfi. Chem. Pharm. Bull. 57, 1081-1088 (2009).
  112. Zhanel, G.G. Sniezek, G.; Schweizer, F.; Zelenitsky, S.; Lagacé-Wiens, P.R.S.; Rubinstein, E.; Gin, A,S.; Hoban, D.J.; Karlowsky, J.A. Ceftaroline: a novel broad-spectrum cephalosporin with activity against meticillin-resistant Staphylococcus aureus. Drugs 69, 809-831 (2009).
  113. Zhang, K.; Teklebrhan, R.B.; Schreckenbach, G.; Wetmore, S.; Schweizer, F. Intramolecular hydrogen bond-controlled prolyl amide isomerization in glucosyl 3'(S)-hydroxy-5'-hydroxymethylproline hybrids: Influence of a C-5'-hydroxymethyl substituent on the thermodynamics and kinetics of prolyl amide cis/trans isomerization. J. Org. Chem. 74, 3735-3743 (2009).
  114. Koizumi, A.; Hada, N.; Kaburaki, A.; Yamano, K.; Schweizer, F.; Takeda, T. Synthetic studies on the carbohydrate moiety of the antigen from the parasite Echinococcus multilocularis. Carbohydr. Res. 344, 856-868 (2009).
  115. Serrano, G.N.; Zhanel, G.G.; Schweizer, F. Antibacterial activity of ultrashort cationic lipopeptides. Antimicrob. Agents Chemother. 53, 2215-2217 (2009).
  116. Zhang, K.; Schweizer, F. Design and synthesis of glucose-templated proline-lysine chimera: polyfunctional amino acid chimera with high prolyl cis amide rotamer population. Carbohydr. Res. 344, 576-585 (2009).
  117. Zhanel, G.G.; DeCorby, M.; Nichol, K.A.; Wierzbowski, A.; Baudry, P.; Karlowsky, J.A.; Lagacé-Wiens, P.R.S.; Walkty, A.; Schweizer, F.; Adam, H.; McCracken, M.; Mulvey, M.; Canadian Antimicrobial Resistance Alliance (CARA); Hoban, D.J. Prevalence of Antimicrobial-Resistant Pathogens in Canadian Hospitals: Results of the Canadian Ward Surveillance Study (CANWARD 2007). Can. J. Infect. Dis. & Med. Micro. 20 (Suppl A), 9A-19A (2009).
  118. Bera, S.; Zhanel, G.G.; Schweizer, F. Design, synthesis and antibacterial activities of neomycin-lipid conjugates: Polycationic lipids with potent gram-positive activity. J. Med. Chem. 51, 6160-6164 (2008).
  119. Mondal, D.; Schweizer, F. Alkylation reactions using a galactose-based β-keto ester enolate and conversion into C-galactosides. Synlett 2475-2478 (2008).
  120. Zhang, K.; Mondal, D.; Zhanel, G.G.; Schweizer, F. Synthesis of glucose-templated lysine analogs and incorporation into the antimicrobial dipeptide sequence kW-OBn. Carbohydr. Res. 343, 1644-1652 (2008).
  121. Zhanel, G.G.; Lam, A.; Schweizer, F.; Thomson, K.; Walkty, A.; Rubinstein, E.; Gin, A.S.; Hoban, D.J.; Noreddin, A.M.; Karlowsky, J.A. Ceftobiprole: A review of a broad spectrum and anti-MRSA cephalosporin. Am. J. Dermatol. 9, 245-254 (2008)
  122. Zuse, A.; Prinz, H.; Müller, K.; Schmidt, P.; Günther, E.G.; Schweizer, F.; Prehn, J.H.M.; Los, M. 9-Benzylidene-naptho[2,3b]thiophen-4-ones and benzylidene-9-(10H)-anthracenones as novel tubulin interacting agents with high apoptosis-inducing activity. Eur. J. Pharm. 575, 34-45 (2007).
  123. Owens, N.W.; Braun, C.; O'Neil, J. D.; Marat, K.; Schweizer, F. Effects of glycosylation of (2S,4R)-hydroxyproline on the conformation, kinetics and thermodynamics of prolyl amide isomerization. J. Am. Chem. Soc. 129, 11670-11671 (2007).
  124. Schweizer, F. Synthesis of fluorescently-labelled and internally quenched UDP-Gal probes. Carbohydr. Res. 342, 1831-1840 (2007).
  125. Owens, N.W.; Braun, C.; Schweizer, F. Tuning of the prolyl trans/cis amide rotamer population by use of C-glucosylproline hybrids. J. Org. Chem. 72, 4635-4643 (2007).
  126. Zhang, K.; Wang, J.; Sun, Z.; Nguyen, D.-H.; Schweizer, F. Synthesis of sugar-lysine chimera with integrated 1,3 hydroxyamine motif. Synlett 239-242 (2007).
  127. Penner, M.; Schweizer, F. Ritter-based glycoconjugation of amino acids and peptides-access to novel glycoconjugates displaying a β-amide linkage between amino acid and sugar moiety. Carbohydr. Res. 342, 7-15 (2006).
  128. Schweizer, F.; Hindsgaul, O. Synthesis of a galacto-configured C-ketoside-based γ-sugar-amino acid and its use in peptide coupling reactions. Carbohydr. Res. 341, 1730-1736 (2006).
  129. Zhang, K.; Schweizer, F. Synthesis of spirocyclic glucose-proline hybrids (GlcProHs). Synlett, 3111-3115 (2005).
  130. Penner, M.N.; Taylor, D.; Desautels, D.; Marat, K.; Schweizer, F. Access to unnatural glycosyl amino acid building blocks via a one-pot Ritter reaction. Synlett, 212-216 (2005).
  131. Schweizer, F.; Hindsgaul, O.; Palcic, M.M. Synthesis of internally fluorescence-quenched sugar nucleotides. Synlett, 1784-1788 (2004).
  132. Schweizer, F. Unusual amino acids accessed through sugar-amino acid hybrids and incorporation into biologically active peptides. Trends Glycosci. Glycotechnol. 15, 315-328 (2003).
  133. Schweizer, F. Glycosamino acids: Building blocks for combinatorial synthesis - Implications for drug discovery. Angew. Chem. Int. Ed. Engl. 41, 230-253 (2002).
  134. Schweizer, F. Combinatorial Chemistry and High Throughput Screening: Preface. Comb. Chem. High T. Scr. 5 (2002).
  135. Lohse, A.; Schweizer F.; Hindsgaul, O. Synthesis of a 56 component library of sugar β-peptides. Comb. Chem. High T. Scr. 5, 389-394 (2002).
  136. Schweizer, F.; Inazu, T. Chain extension of sugar δ-lactones with the enolate of tert-butyl bromoacetate and elaboration into functionalized C-ketosides, C-glycosides, and C-glucosyl glycines. Org. Lett. 3, 4115-4118 (2001).
  137. Schweizer, F.; Otter, A.; Hindsgaul, O. Synthesis of sugar-fused GABA-analogs. Synlett, 1743-1746 (2001).
  138. Schweizer, F.; Lohse, A.; Otter, A.; Hindsgaul, O. One pot conversion of ketoses into sugar-β-peptides via a modified intramolecular Ritter reaction. Synlett, 1434-1436 (2001).
  139. Schweizer, F.; Hindsgaul, O. Combinatorial synthesis of carbohydrates. Curr. Opin. Chem. Biol. 3, 291-297 (1999).
  140. Schweizer, F. Glycomimetic probes for the study of galactose-binding proteins, Ph.D. thesis, University of Alberta, Edmonton, Canada, (1999).
  141. Schweizer, F.; Jiao, H.; Hindsgaul, O.; Wong, W.Y.; Irvin, R.T. Interaction between the pili of Pseudomonas aeruginosa PAK and its carbohydrate receptor β-D-GalNAc (1-4) β-D-Gal analogs. Can. J. Microbiol. 44, 307-311 (1998).
  142. Campbell, A.P.; Wong, W.Y.; Houston Jr, M.; Schweizer, F.; Cachia, P.J.; Irvin, R.T.; Hindsgaul, O.; Hodges R.S.; Sykes, B.D. Interaction of the receptor binding domains of Pseudomonas aeruginosa pili strains PAK, PAO, KB7 and P1 to a cross-reactive antibody and receptor analog: Implications for synthetic vaccine design. J. Mol. Biol. 267 382-401 (1997).
  143. Lehmann J.; Schweizer, F.; Weitzel, U.P. Erratum: Synthesis of photolabile mono and divalent α-D-mannoside-6-phosphates as chemically modifying probes for mannose-6-phosphate receptors (Carbohydr. Res. (1995), 270, (181-189)). Carbohydr. Res. 273 (1995).
  144. Holland, H.L.; Manoharan, T.S.; Schweizer, F. Preparation of homochiral chroman-4-ol and thiochroman-4-ol by microbial biotransformation. Tetrahedron Assym. 2, 335-338 (1991).

Books/Comments

  1. Owens, N.W.; Schweizer, F. Peptides and glycopeptides. In Comprehensive Biotechnology, 3rd ed.; Moo-Young, M., Ed.; Elsevier, 2019; pp. 98-115.
  2. Gaweł, W.; Schweizer F. Overview of technologies applied for biomaterial production-3D printing. In Stem Cells and Biomaterials for Regenerative Medicine; Łos, M.J., Hudecki, A., Wiecheć, E., Eds.; Elsevier, 2015; pp. 99-120.
  3. Arthur, G.; Schweizer, F.; Ogunsina, M. Synthetic Glycosylated Ether Glycerolipids as Anticancer Agents. In Carbohydrates in Drug Design and Discovery; Jimenez-Barbero, Cañada, F.J., Martin-Santamaria, S., Eds.; Royal Society of Chemistry: Cambridge, 2015.
  4. Gorityala, B.K.; Guchhait, G.; Schweizer, F. Amphiphilic Aminoglycoside Antimicrobials in Antibacterial Drug Discovery. In Carbohydrates in Drug Design and Discovery; Jimenez-Barbero, Cañada, F.J., Martin-Santamaria, S., Eds.; Royal Society of Chemistry: Cambridge, 2015.
  5. Owens, N.W., Schweizer, F. Peptides and glycopeptides. In Comprehensive Biotechnology, 2nd ed.; Moo-Young, M., Ed.; Elsevier, 2011; pp. 122-138.
  6. Banerji, S.; Ande, R.S.; Maddika, S.; Banerji, S.; Rashedi, I.; Owens, N.W.; Zuse, A.; Schweizer, F.; Los, M. Peptides and peptidomimetics as cancer therapy sensitizing agents. In Sensitization of cancer cells for chemo/immuno/radio-therapy; Bonavida, B., Ed.; Humana Press, 2008; pp. 279-304.
  7. Schweizer, F. Engineering carbohydrate scaffolds into the side chains of amino acids and use in combinatorial synthesis. In Handbook of Carbohydrate Engineering; Yarema, K.Y., Ed.; Taylor & Francis: Boca Raton, 2005; pp. 749-780.
  8. Holland, H.L.; Schweizer, F.; Manoharan, T.S. Reduction of an aromatic ketone. In Preparative Biotransformations; Roberts, S.M., Ed.; Wiley & Sons: Chichester, 1992.