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Associate Professor My research utilizes molecular biology techniques in conjunction with physiological and metabolic studies to study the hemoglobin oxygen-affinity, energetics and evolutionary physiology of shrews and moles (and other semi-aquatic mammals), with a focus on the specializations these insectivores have evolved to cope with hypoxia/hypercapnia and temperature. Our lab is also actively spearheading several projects that are focused on elucidating the functional/structural properties and physiochemical evolution of authentic gene products resurrected from DNA sequences of extinct mammalian species. Funding for my research is primarily provided by grants from the NSERC Discovery and Discovery Accelerator Supplement Programs. |
| 2011-2012 Courses Taught: |
Human Physiology 2 (BIOL 2420) Environmental Physiology of Animals 1 (BIOL 3470) Comparative Animal Energetics (BIOL 4460) |
Representative Publications: |
Campbell, K.L., J.F. Storz, A.V. Signore, H. Moriyama, K.C. Catania, A. Payson, J. Bonaventura, J. Stetefeld and R.E. Weber. 2010. Molecular basis of a novel adaptation to hypoxic-hypercapnia in a strictly fossorial mole. BMC Evolutionary Biology, 10:214. [PDF] Campbell, K.L., J.E.E. Roberts, L.N. Watson, J. Stetefeld, A.M. Sloan, A.V. Signore, J.W. Howatt, J.R.H. Tame, N. Rohland, T-J. Shen, J.J. Austin, M. Hofreiter, C. Ho, R.E. Weber† and A. Cooper†. 2010. Substitutions in woolly mammoth hemoglobin confer biochemical properties adaptive for cold tolerance. Nature Genetics, 42(6):536-540. [PDF][supporting information] Opazo, J.C, A.M. Sloan, K.L. Campbell† and J.F. Storz†. 2009. Origin and ascendency of a chimeric fusion gene: the β/δ-globin gene of paenungulate mammals. Molecular Biology and Evolution, 26(7):1469-1478. [PDF] |
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CONTACT: |
Tel: (204) 474-6397 Fax: (204) 474-7588 Email: campbelk  cc.umanitoba.ca
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Last update January 24, 2012 |
