Tranmer Research Group

Welcome to the Tranmer Research Group Website

Principal Investigator: Geoffrey K. Tranmer, PhD

Tenured Associate Professor in the College of Pharmacy, University of Manitoba.

orcid.org/0000-0002-9774-8685

Senior Research Chemist, Merck Frosst Canada Ltd.

NSERC Post-Doctoral Fellow, University of Cambridge, Supervisor: Prof. Steven V. Ley.

Post-Doctoral Fellow, Princeton University, Supervisor: Prof. Martin Semmelhack.

PhD, University of Guelph, Organic Chemistry, Supervisor: Prof. William Tam.

BSc (Hons), Brock University, Chemistry, Supervisor: Prof. Fred Capretta.

Publications

Principal Investigator: (2014 - Present)

48. Vuong, B.; Fang, Y.; Tranmer, G. K. An optimized fluorescence assay for screening novel PARP-1 inhibitors. Can. J. Chem., 2024, In Press. (DOI: 10.1139/cjc-2024-0047). Link to paper.
47. Sanghai, N.; Vuong, B.; Burak Berk, A.; Afridi, M. S. K.; Tranmer, G. K. Current small molecule-based medicinal chemistry approaches for neurodegeneration therapeutics. ChemMedChem, 2024, e202300705. (DOI: 10.1002/cmdc.202300705). Link to paper.
46. Tranmer, G. K.; Sanghai, N. 1H-Pyrazole analogues and methods and uses thereof. International Patent Application No. PCT/CA2023/051352. October 12th, 2023.
45. Shang, Yu; Zhong, Z; Fang, Y; Patel, R; Li, Q; Li, H; Xu, L; Sagona-Stophel, S; Mer, E; Thomas, S; Meng, Y; Li, Z; Yang, Y; Wang, Z; Guo, N; Zhang, W; Tranmer, G; Dong, Y; Wang, Y; Tang, J; Li, C; Walmsley, I; Guo, G. A universal programmable Gaussian Boson Sampler for drug discovery. Nature Computational Science, 2023, 3(10), 839 – 848. (DOI: 10.1038/s43588-023-00526-y). Link to paper.
44. Sanghai, N.; Tranmer, G. K. Biochemical and Molecular Pathways in Neurodegenerative Diseases: An Integrated View. Cells, 2023, 12(18), 2318. (DOI: 10.3390/cells12182318). Link to paper.
43. Tranmer, G. K.; Hasinoff, B. B. Camptothecin (CPT) derivative(s) and methods and uses thereof. International Patent Application No. PCT/CA2022/050440., March 24th, 2022.
42. Messner, K.; Vuong, B.; Tranmer, G. K. The Boron Advantage: The Evolution and Diversification of Boron?s Applications in Medicinal Chemistry. Pharmaceuticals, 2022, 15(2), 264. (DOI: 10.3390/ph15030264). Link to paper.
41. Sanghai, N.; Tranmer, G. K. Hydrogen Peroxide and Amyotrophic Lateral Sclerosis: From Biochemistry to Pathophysiology. Antioxidants, 2022, 11(1), 52. (DOI: 10.3390/antiox11010052). Link to paper.
40. Sanghai, N.; Tranmer, G. K. COVID-Toe ? The silent symptom: Raising awareness among health care professionals and community. Current Molecular Medicine , 2022, 22(7), 563 – 566. (DOI: 10.2174/1566524021666211013121116). Link to paper.
39. Sanghai, N.; Tranmer, G. K. Taming the cytokine storm: Repurposing Montelukast for the attenuation and prophylaxis of severe COVID-19 symptom. Drug Discovery Today, 2020, 25(12), 2076 – 2079. (DOI: 10.1016/j.drudis.2020.09.013). Link to paper.
38. Sanghai, N.; Shafiq, K.; Tranmer, G. K. Drug discovery by drug repurposing: combating COVID-19 in the 21st century. Mini-Reviews in Medicinal Chemistry, 2020, 20(1), 3 – 9. (DOI: 10.2174/1389557520999200824103803) Link to paper.
37. Majdinasab, A.; Manna, P.; Wroczynsky, Y.; Van Lierop, J.; Cicek, N.; Tranmer, G. K.; Yuan, Q. Cost-Effective Zeolite Synthesis from Beverage Waste Glass Cullet Using Energy Efficient Microwave Radiation. Materials Chemistry and Physics, 2019, Volume 221, 272-287. (DOI: 10.1016/j.matchemphys.2018.09.057). Link to paper.
36. Liang, D.; Wu, X.; Hasinoff, B. B.; Herbert, D. E.; Tranmer, G. K. Evaluation of Nitrobenzyl Derivatives of Camptothecin as Anti-Cancer Agents and Potential Hypoxia Targeting Prodrugs. Molecules, 2018, Online August 15, 2018. (DOI: 10.3390/molecules23082041). Link to paper.
35. Bao, J.; Kuik, D.; Tranmer, G. K. An efficient one-pot synthesis of N,N′-disubstituted phenylureas and N-aryl carbamates using hydroxylamine-O-sulfonic acid. Tetrahedron, 2018, Online May 29, 2018. (DOI: 10.1016/j.tet.2018.05.072). Link to paper.
34. Kuik, D.; McCubbin, J. A.; Tranmer, G. K. Sonication and microwave-assisted primary amination of potassium aryl trifluoroborates and phenylboronic acids under metal-free conditions. Synthesis, 2017, 2555 – 2561. (DOI: 10.1055/s-0036-1588148). Link to paper.
33. Fang, Y.; Tranmer, G. K. Expedited access to thieno[3,2-c]quinolin-4(5H)-ones and benzo[h]-1,6-naphthyridin-5(6H)-ones via a continuous flow photocyclization method. Organic & Biomolecular Chemistry, 2016, 10799 – 10803. (DOI: 10.1039/C6OB02279K). Link to paper.
32. Fang, Y.; Tranmer, G. K. Continuous flow photochemistry as an enabling synthetic technology: Synthesis of substituted-6-(5H)-phenanthridinones for use as poly(ADP-ribose) polymerase inhibitors. Medicinal Chemical Communications, 2016, 7, 720 – 724. Link to paper.
31. Bao, J.; Tranmer, G. K. The solid copper-mediated C-N cross-coupling of phenylboronic acids under continuous flow conditions. Tetrahedron Letters, 2016, 57(6), 654 – 657. Link to paper.
30. Liang, D.; Miller, G. H.; Tranmer, G. K. Hypoxia activated prodrugs: Factors influencing design and development. Current Medicinal Chemistry, 2015, 22(37), 4313 – 4325. Link to paper.
29. Gverzdys, T.; Hart, M. K.; Pimentel-Elardo, S.; Tranmer, G. K.; Nodwell, J. R. 13-Deoxytetrodecamycin, a new tetronate ring-containing antibiotic that is active against multidrug-resistant Staphylococcus aureus. Journal of Antibiotics, 2015, 68(11), 698 – 702. Link to paper.
28. Manansala, C.; Tranmer, G. K. Flow synthesis of 2-methylpyridines via alpha-methylation. Molecules, 2015, 20(9), 15797 – 15806. Link to paper.
27. Bao, J.; Tranmer, G. K. The utilization of copper flow reactors in organic synthesis. Chemical Communications, 2015, 51(15), 3037 – 3044. Link to paper.
26. Nagireddy, J. R.; Tranmer, G. K.; Carlson, E.; Tam, W. N-O Cleavage reactions of heterobicycloalkene-fused 2-isoxazolines. Beilstein Journal of Organic Chemistry, 2014, 10, 2200 – 2205. Link to paper.

Industrial Publications and Patents:

25. Lachance, N.; Gareau, Y.; Guiral, S.; Huang, Z.; Isabel, E.; Leclerc, J. P.; Leger, S.; Martins, E.; Nadeau, C.; Oballa, R. M.; Ouellet, S. G.; Powell, D. A.; Ramtohul, Y. K.; Tranmer, G. K.; Trinh, T.; Wang, H.; Zhang, Z. Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series. Bioorg. Med. Chem. Lett. 2012, 22(2), 980 – 984.
24. Gauthier, J.; Belley, M.; Deschenes, D.; Fournier, J-F.; Gagne, S.; Gareau, Y.; Hamel, M.; Henault, M.; Hyjazie, H.; Kargman, S.; Lavallee, G.; Levesque, J-F.; Li, L.; Mamane, Y.; Morin, N.; Mancini, J.; Mulrooney, E.; Robichaud, J.; Therien, M.; Tranmer, G. K.; Wang, Z.; Wu, J.; Black, W. C. The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y14. Bioorg. Med. Chem. Lett. 2011, 21(10), 2836 – 2839.
23. Guay, D.; Beaulieu, C.; Belley, M.; Crane, S.; DeLuca, J.; Gareau, Y.; Hamel, M.; Henault, M.; Hyjazie, H.; Kargman, S.; Chan, C. C.; Xu, L.; Gordon, R.; Li, L.; Mamane, Y.; Morin, N.; Mancini, J.; Therien, M.; Tranmer, G. K.; Truong, V. L.; Wang, Z.; Black, W. C. Synthesis and SAR of pyrimidine-based, non-nucleotide P2Y14 receptor antagonists. Bioorg. Med. Chem. Lett. 2011, 21(10), 2832 – 2835.
22. Fortin, R.; Lachance, N.; Li, C. S.; Tranmer, G. Preparation of novel spiro compounds useful as inhibitors of stearoyl-CoA delta-9 desaturase. PCT Int. appl. 2011, pp. 77, WO 2011047481.
21. Lachance, N.; Leger, S.; Oballa, R. M.; Powell, D.; Tranmer, G. K.; Martins, E.; Gareau, Y. Preparation of phenylhexahydropyrrolopyrrolythiazolyltetrazolylacetic acid derivatives and analogs for use as stearoyl-coenzyme A delta-9 desaturase inhibitors. PCT Int. appl. 2010, pp. 107, WO 2010108268.
20. Isabel, E.; Lachance, N.; Leclerc, J-P.; Leger, S.; Oballa, R. M.; Powell, D.; Ramtohul, Y. K.; Roy, P.; Tranmer, G. K.; Aspiotis, R.; Li, L.; Martins, E. Preparation of heterocyclic derivatives as inhibitors of stearoyl-CoA delta-9 desaturase (SCD). PCT Int. appl. 2010, pp. 172, WO 2010094126.
19. Powell, D.; Tranmer, G. K. Preparation of azetidine derivatives as inhibitors of stearoyl-coenzyme A delta-9 desaturase. PCT Int. appl. 2010, pp. 55, WO 2010043052.
18. Belley, M.; Deschenes, D.; Fortin, R.; Fournier, J-F.; Gagne, S.; Gareau, Y.; Gauthier, J. Y.; Li, L.; Robichaud, J.; Therien, M.; Tranmer, G. K.; Wang, Z. Preparation of substituted 2-naphthoic acids as antagonists of GPR105 activity. PCT Int. appl. 2009, pp. 92, WO 2009070873.
17. Guay, D.; Beaulieu, D.; Belley, M.; Crane, S. N.; De Luca, J.; Fortin, R.; Gareau, Y.; Li, L.; Therien, M.; Tranmer, G. K.; Troung, V. L.; Wang Z. Preparation of phenyl-dihydropyridopyrimidinecarboamide derivatives for use as GPR105 antagonists. PCT Int. appl. 2008, pp. 85, WO 2009000087.

Student and Post-Doctoral Publications:

16. Baxendale, I. R.; Hayward, J. J.; Ley, S. V.; Tranmer, G. K. Pharmaceutical strategy and innovation: an academics perspective. ChemMedChem 2007, 2(6), 768-788.
15. Smith, C. D.; Baxendale, I. R.; Tranmer, G. K.; Baumann, M.; Smith, S. C.; Lewthwaite, R. A.; Ley, S. V. Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor. Org. Biomol. Chem. 2007, 5(10), 1562-1568.
14. Tranmer, G. K., Baxendale, I. R.; Ley, S. V.; Smith, C. D. A Flow Reactor Process for the Synthesis of Peptides Utilizing Immobilized Reagents, Scavengers and Catch and Release Protocols. Chem. Commun. 2006, 4835-4837.
13. Baumann, M.; Baxendale, I. R.; Ley, S. V.; Smith, C. D.; Tranmer, G. K. Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles. Org. Lett. 2006, 8(23), 5231-5234.
12. Baxendale, I. R.; Griffiths-Jones, C. M.; Ley, S. V.; Tranmer, G. K. Microwave Assisted Suzuki Coupling Reactions using an Encapsulated Palladium Catalyst for Batch and Continuous Flow Transformations. Chem. Eur. J. 2006, 12(16), 4407-4416.
11. Tranmer, G. K.; Baxendale, I. R.; Deeley, J.; Griffiths-Jones, C. M.; Ley, S. V.; Saaby, S. A Flow Process for the Multi-Step Synthesis of the Alkaloid Natural Product Oxomaritidine: A New Paradigm for Molecular Assembly. Chem. Commun. 2006, 2566-2568.
10. Baxendale, I. R.; Griffiths-Jones, C. M.; Ley, S. V.; Tranmer, G. K. Preparation of the neolignan natural product grossamide by a continuous-flow process. Synlett 2006, 427-430.
9. Tranmer, G. K.; Tam, W. Bis(η2-ethene)(2,4-pentanedionato-O,O’)rhodium. In “Encyclopedia of Reagents for Organic Synthesis”, Editors: Paquette, L.; Rigby, J.; Wipf, P., John Wiley & Sons Ltd. 2003, article number RN00230.
8. Tranmer, G. K.; Tam, W. Bis(2-phenylindenyl)zirconium dichloride. In “Encyclopedia of Reagents for Organic Synthesis”, Editors: Paquette, L.; Rigby, J.; Wipf, P., John Wiley & Sons Ltd. 2003, article number RN00229.
7. Tranmer, G. K.; Tam, W. Molybdenum-mediated Cleavage Reactions of Isoxazoline Rings Fused in Bicyclic Frameworks. Org. Lett. 2002, 4(23), 4101-4104.
6. Tranmer, G. K.; Tam, W. Palladium-Catalyzed Sonogashira Coupling of 2,3-Dibromonorbornadiene: Synthesis of Symmetrical and Unsymmetrical Norbornadiene-2,3-diynes. Synthesis 2002, 1675-1682.
5. Tranmer, G. K.; Tam, W. Intramolecular 1,3-dipolar cycloadditions of norbornadiene-tethered nitrones. J. Org. Chem. 2001, 66(15), 5113-5123.
4. Yip, C.; Handerson, S.; Tranmer, G. K.; Tam, W. Intramolecular 1,3-dipolar cycloadditions of norbornadiene-tethered nitrile oxides. J. Org. Chem. 2001, 66(1), 276-286.
3. Tranmer, G. K.; Keech, P.; Tam, W. Intramolecular 1,3-dipolar cycloadditions of 2-substituted norbornadiene-tethered nitrones. Chem. Commun. 2000, 863-864.
2. Tranmer, G. K.; Yip, C.; Handerson, S.; Jordan, R. W.; Tam, W. Synthesis of 2,3-disubstituted norbornadienes. Can. J. Chem. 2000, 78(5), 527-535.
1. Tranmer, G. K.; Capretta, A. Intermolecular carbenoid insertions: reactions of 2-substituted thiophenes with ethyl diazoacetate in the presence of rhodium(II) acetate. Tetrahedron 1998, 54(51), 15499-15509.

Awards:

Coming Soon!

Research Interests

• Medicinal Chemistry, Drug Discovery, Chemical Biology, Organic Synthesis

• Flow Chemistry: Development and application of new synthetic technologies in medicinal chemistry and chemical biology programs

• Development of targeted cancer therapies

• Development of novel bioconjugation methodologies for use in chemical biology

Contact Information

Geoff Tranmer, PhD

Associate Professor

College of Pharmacy

University of Manitoba

321 Apotex Centre

750 McDermot Ave

Winnipeg, MB, R3E 0T5

Tel. 204-474-8358

Email: Geoffrey.Tranmer(at)umanitoba.ca