UM
  Laboratory of RNA Biology


Xie Lab


Lab Members


Research


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Xie Lab Members




Name
 Position Room, phone
Jiuyong Xie Principal Investigator (Faculty Website)
 Rm 439, +1-204 975-7774 (O)
Samuel Ogunsola*
 PhD Student Rm  440, +1-204 975-7740
Karl Zhang Undergraduate
Aydan Wang** Assistant

*: Winner of

**: Our Rising Hockey Star:


Funding agencies for lab members:
CIHRlogoNSERClogoRM


Keywords: molecular biology, RNA, processing, alternative splicing, cryptic splicing, transcriptome integrity, hnRNP, gene regulation, gene expression, evolution, proteomic diversity, complexity, splicing factors, protein kinases, cell signaling, neurons, endocrine cells, SNP, mutation, cancer, GWAS, human health/genetic diseases

Highlights of some of the findings by the lab:

hs3ssbar


BP
Splice Site Matrices of >1000 Species/lineages

REPAG_GenomesR38R91


 REPAG
(Right-click image to view details)

The REPAG element specifically among mammals
(Sohail M., and Xie J. Molecular & Cellular Biology, 2015, 35(12): 2203-2214)

Adaptive splicing
(Right-click to view details)
Adaptive splicing

CaRRE
(Right-click image to view details)

The CaRRE element among vertebrates (Liu GD, et al., J. Biol. Chem. 2012, 287:22709–22716)

STREX model
Molecular basis of the depolarization-regulated alternative splicing of the STREX exon of the Slo1 gene

hnrnpl-prolactin
Importance of proper splicing control in hormone production: aberrant splice variant of prolactin (right) due to the loss of hnRNP L

REPA

A new group of introns: REPA element 'inserted' between the Py and 3'AG and its effects on alternative splicing

hREPAG
Consensus of 1000 human REPAG intron ends (Credit: Aydan Wang)

*Research in this lab has been supported by CIHR , NCIC, CBCF, NSERC, MMSF, MHRC and CFI.


Misce. links:



Faculty of Graduate Studies

Department of Physiology & Pathophysiology

College of Medicine

Faculty of Health Sciences

University of Manitoba