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Laboratory
of RNA Biology
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| We are interested in understanding how the different fragments of a gene are selectively combined (spliced) to produce multiple products in biology and diseases. |
| This process, called pre-mRNA splicing, has profound implications in the evolution and functional complexity of genes/gene products. Its disruption is a cause of human genetic diseases by many mutations and also of the aberrant splicing in cancers. Our past research has focused on the molecular basis of adaptive splicing, likely involved in cell adaptation, neuron homeostasis and neurological diseases. This has also allowed us to discover and extend the scope to a novel class of introns/splice sites (REPA-harbouring) contributing to the evolution of alternative splicing, gene product diversity or to the prevention of aberrant splicing in human health/diseases. Here are more DETAILS. Particularly welcome to join us are students with backgrounds in biochemistry, genetics, computer science or statistics. |
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The REPAG element specifically
among mammals |
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The CaRRE element among
vertebrates (Liu GD, et al., J. Biol.
Chem. 2012, 287:22709–22716) |
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A new group of
introns: REPA element 'inserted' between the
Py and 3'AG and its effects on alternative
splicing |
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*Research in this lab has been supported by CIHR , NCIC, CBCF, NSERC, MMSF, MHRC and CFI.
Misce. links:
- Eradication of Polio in China
RNA Meeting in
Winnipeg, June 23-26, 2019 Some RNA/DNA
literature/history:- Why are the snRNAs in splicing called
U1, U2, U4, U5, U6 snRNAs? Here is the original paper
that describes the use of Us in the names for some of
the small nuclear RNAs that are Uridylic acid-rich, by
James L. Hodnett and Harris Busch of the Baylor
University College of Medicine in 1968: Hodnett JL,
Busch H. Isolation and characterization of uridylic
acid-rich 7 S ribonucleic acid of rat liver nuclei. J
Biol Chem. 1968 Dec 25;243(24):6334-42. |PDF|
- 125 Questions in
Science,
which ones are related to Alternative Splicing?
- How to present a clean, highlight
revision text without the deleted words in the
text or balloons after tracking changes in WORD?
- Albert Einstein the mediocre:
Why the h-index is a bogus measure of academic
impact (Reader discretion is advised).
- Sequencing RNA and its
modifications Webinar
- Opinions about the term non-coding RNA
- 谁翻译了基 因一词？维 基百科
Faculty of Graduate Studies |
Department of Physiology & Pathophysiology |
College of Medicine |
Faculty of Health Sciences |
University of Manitoba |